I've tried all kinds of cases. Started with Otterbox Defender, then tried the Armor series when it came out (big heavy thing, even compared to Defender), then tried the Lifeproof cases, which are ok, but eh, still prefer the Defender and now only buy the Defender. Yes, it's big, it's bulky, etc, but it's tough. Really tough. A couple months ago I made a post about having my phone ran over. Long story short, I was riding my motorcycle to work, and phone was in my RAM mount, which is on the handlebars on the bike. At about 65mph,the phone flew out of my mount, hit my shoulder, then skyrocketed into the air. I looked back in time to see my phone gaining altitude, then proceed to come crashing down in the roadway, then get hit by a Honda Accord, then get ran over by the truck behind it. Well crud. I pull over, ride back on the shoulder, find the wreckage. It looks bad, but when I pick up the pieces, phone was working. I snapped case back together, and all is well. Phone is bent a little, but it works perfectly, not a scratch on it, screen isn't cracked, AND the case snapped back together and is still on the phone.
Not only that, but I'm a warehouse manager, so I'm out in the shop a lot, and my phone gets banged and dropped all the time. Up until this one got ran over, all my phones have come out looking brand new after a couple years in an Otterbox Defender.
I'll add that I hate the screen protector, so I pop that out before installing on phone.
EDIT: Also, check for sales. Defenders do go on sale, and can be had for $30, sometimes less. I got mine from BestBuy for $15. It was on super sale, and only had black, but it was cheap. Amazon has them often too, usually $25 or less.